BCRB 2018

19/09/2018

PARP inhibition and BRCA status

Polyak K Nat Med 2011

31

Clinical trials: PARP inhibitors + radiotherapy

• Several ongoing trials (clinical trials.gov) • Veliparib With Radiation Therapy in Patients With Inflammatory or Loco- regionally Recurrent Breast Cancer • Olaparib and Radiotherapy in Inoperable Breast Cancer • Olaparib and Radiotherapy in Inoperable Breast Cancer • A Trial Evaluating Concurrent Whole Brain Radiotherapy and Iniparib in Multiple Non Operable Brain Metastases • …

32

16