BCRB 2018

19/09/2018

Hypoxia

Micro- environment

Glucose, Glutamine

pH, lactate

Contextual lethality

Contextual lethality

• High specificity • Low toxicity (different from RT) • Interaction with RT • Radiosensitivity • Hypoxia • Proliferation • Therapeutic index • Target driven • Synthetic lethality • Contextual lethality • Immune modulation

Hanahan & Weinberg Cell 2011

17