BCRB 2018

19/09/2018

T-cell trafficking, infiltration, killing

Herrera FG et al CA Cancer J Clin 2017

• Antibodies directed against coinhibitory T-cell receptors (TCR) or TGF- blocking drugs • E.g. PD-1 or PD-L1 antibodies (pembrolizumab, nivolumab)

Ribas, NEJM 2015

Rationale for combination with anti-PD-L1 Ab

Golden et al., Lancet Oncology, 2015 and Frey, Gaipl, Lancet Oncology,

Radio(chemo)-immunotherapy: works with various solid tumors

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