BCRB 2018

19/09/2018

Radioimmunotherapy combinations: challenges

• Define optimal RT dose/fractionation schemes to create maximal interactions with IT • Identify type, dose and schedule of immunogenic chemotherapy and type and schedule of immunomodulatory drugs for combination with chemo-RT • Role of particle radiation and radionuclide therapy for their potential immunomodulatory effects

Dose scheduling for RT+IT combinations

13 patients

Immunotolerance increased early after the initiation of Ipilimumab

Sundahl et al, Int J Rad Onc Biol Phys 2018

25