BCRB 2018

Lung • Retreatment tolerance of the mouse lung

pneumonitis

14

treatment alone

Initial dose <50% tolerance: full recovery , 2 months Higher initial doses: partial recovery , 3 months

12

post 6 Gy

10

post 8 Gy

Retreatment-LD50 (Gy) 6 8

post 10 Gy

Only applies for pneumonitis phase: retreatment tolerance fibrosis might be poorer

0

1

2

3

4

5

6

Time after first treatment (months)

Terry Int J Radiat Oncol Biol Phys 1988