BCRB 2018

Kidney • Retreatment tolerance mouse kidney

10 12 14

6.5 mo post 6 Gy

No recovery between 1 day and 6 months after initial treatment Progression of (subclinical) damage Retreatment tolerance decreases with time Extreme caution when re- irradiating kidneys!

Reduced kidney function 0 2 4 6 8

2 wks post 6 Gy

treatment alone

Reirradiation dose (Gy) 0 2 4 6 8 10 12 14 16

Stewart Int J Radiat Oncol Biol Phys 1989