BCRB 2018

Urinary bladder • Retreatment tolerance mouse bladder

20

No recovery between 1 day and 9 months after initial treatment Progression of (subclinical) damage results in shortening of latent times after retreatment Extreme caution when re-irradiating urinary bladder!

15

2F / 9 mo

10

2F / 1 d

micturition frequency 0 5

2F / 3 mo

total dose (Gy) 0 5 10 15 20 25 30 35

Stewart Int J Radiat Oncol Biol Phys 1990