Basic Clinical Radiobiology 2017

Combined chemo- and radiotherapy treatment: Cellular / molecular interaction

Topo-isomerase inhibitor

DNA damage Chromosome Cell Apoptosis induction repair aberration Cycle

Etoposide Camptothecine Adriamycine

- ? ?

± +? ?

± - -

+ + -/+

? + -/+

ESTRO 2017

Combined chemo- and radiotherapy treatment: Cellular / molecular interaction

Anti-microtubule agents

DNA damage Chromosome Cell Apoptosis induction repair aberration Cycle

Vinca-alcaloides Taxanes

? ?

- -

? +

+ +

? +

ESTRO 2017