Basic Clinical Radiobiology 2017

Modulation of regrowth delay in SA-NH tumor by fractionated irradiation and fludarabine administration

Fludarabine (400 mg/ kg) q.d. x4 4.5 Gy q.d. x4

11 13 15

control

5 7 9

Fludarabine 3h prior to RT

Mean tumor diameter ± se (mm)

0 5 10 15 20 25 Time after first fraction (day)

ESTRO 2017

THE CONCEPT OF THERAPEUTIC RATIO

DMF = 2.0

Tumor radiosensitization

Normal tissue radio-toxicity

DMF = 1.2

EFFICACY

Therapeutic Ratio = DMF T DMF NT

ESTRO 2017