Basic Clinical Radiobiology 2017

Dose-painting by number (DPBN)

SCC oropharynx: T4b-N0-M0

PTV-T 86 Gy

PTV-T 70 Gy

R parotid

L parotid

PTV-N left 56 Gy

PTV-N right 56 Gy

Brain stem

Spinal cord

ESTRO 2017

Courtesy of S. Differding, 2012

Which biological pathways? …

Hypoxia: 18 F-EF3

Metabolism: 18 F-FDG 11 C-Met

Proliferation: 76 Br-BFU

ESTRO 2017