Basic Clinical Radiobiology 2017

D ADC during RT: result

2 weeks: ΔADC: +27%: no LR

2 weeks ΔADC: +9%: LR

ESTRO 2017

Courtesy of S. Nuyts

Randomized trials on dose painting / dose escalation in locally advanced HNSCC

Acronym Stage

Molecular imaging

Design

Due date

Xuzhou Medical College, China III-IV§ F-Miso PET and FDG-PET

RT-CH >< dose escalation on FDG >< dose escalation on F-Miso

Dec J015?

De Neve*

II-IV FDG-PET 69 Gy IMRT >< 84 Gy IMRT

Q1 2018

Eisbruch*

70 Gy + carbo/cddp >< 80 Gy + carbo/cddp Dec 2020

III-IV DCE-MRI

INTELHOPE* III-IV FDG-PET 66 Gy + cddp >< 73.5 Gy + cddp

Dec 2020 Dec 2022

Zips*

III-IV F-Miso PET

70 Gy + CH >< 77 Gy +CH

Escalox (Munich)

> July 2015

III

F-Miso PET 70 Gy + CDDP (w1, w5) >< 80.6 Gy + CDDP (w1, w5)

§ nasopharyngeal carcinoma * randomized phase-II

ESTRO 2017

ClinicalTrials.gov, April 2017