Basic Clinical Radiobiology 2017

Prototypes of modified fractionation

• Hyperfractionation (HF) • Accelerated fractionation (AF)

• (Hybrid schedules) • Hypofractionation

ESTRO 2017

Hypofractionation (HypoF) Increased dose per fraction (> 2.0 Gy)

Conventional

CF

60Gy/ 2.0 Gy/ 6w

Moderate Hypo F (curative)

m HypoF

75Gy/ 2.5 Gy/ 5w

Curative RT

HypoF

67.5 Gy/13.5 Gy/ 2w

Palliative RT

HypoF

to

SD 8 Gy 30 Gy/ 3.0 Gy/ 2w

ESTRO 2017