Basic Clinical Radiobiology 2017

0 40 50 60 70 80 90 100 HYPOFRACTIONATION I HYPERFRACTIONATION 1.0 Gy d/Fr = 1.6 Gy 4 - 5 Gy 1.2 Gy 2 Gy Tumor with a/b = 10 Gy Late complications a/b = 3 Gy Current data with prostate tumors at a/b = 1.5 Gy Total Iso-effect Dose (Gy) Number of dose fractions Radiobiological and clinical issues in IMRT for prostate C Courtesy of K. Haustermans 20 40 60 80

ESTRO 2017

Conformal irradiation for prostate tumors

3D- CRT

IMRT

≥ grade 2 proctitis: 15% >< 5% (p= 0.01)

ESTRO 2017

Dearlaney, 1999