Brain Tumours

IMPACT OF WBRT ON COGNITIVE FUNCTIONS : GENERAL CONCEPTS IN BRAIN METASTASIS • A radiation-induced dementia with ataxia and urinary incontinence has been reported in up to 30% of patients by 1 year from receiving unconventional large size fractions of WBRT (6-8.5 Gy) ( De Angelis et al, Neurology, 1989 ). • When using more conventional size fractions (up to 3 or 4 Gy per fraction) the incidence of cognitive deficits in long-term survivors is unknown. • Long-term survivors frequently develop overtime changes on MRI, such as cortical atrophy, hyperintensity of the white matter in T 2 / FLAIR images and hydrocephalus, but the clinical concomitants are poorly known.