Brain Tumours

NEW APPROACHES TO MINIMIZE COGNITIVE DECLINE FOLLOWING WBRT (“GENTLER WBRT”)

• Use of “protective” drugs (memantine) (RTOG 0614) • Hippocampus avoidance with intensity modulated radiotherapy (RTOG 0933) • Anti-inflammatory compounds • Identification of subgroups of patients at higher risk of developing cognitive deficits

Gondi and Mehta, Curr Opin Neurol 2010; Steeg et al, Nat Rev Cancer 2011