Brain Tumours

RATIONALE FOR NEUROPROTECTIVE DRUGS IN ASSOCIATION WITH WBRT • The pathogenesis of the radiation-induced damage could be similar to that of the small vessel disease of vascular dementia: injury of the endothelium → accelerated atherosclerosis → chronic ischemia ↓ To investigate compounds with efficacy in vascular dementia • Memantine is a non-competitive, low affinity antagonist of the N- methyl-D-aspartate (NMDA) receptor, which is activated by glutamate, and has the potential to block the excessive NMDA stimulation following ischemia.