Brain Tumours

Efficacy outcomes – by molecular diagnosis/therapy

RT (A)

ChT (B/C)

RT (A)

ChT (B/C)

RT (A)

ChT (B/C)

IDHwt

IDHmut

Non-Codel (n=40)

Non-Codel (n=43)

Codel (n=35)

Codel (n=31)

(n=28)

(n=30)

PFS [years] TTF [years]

0.8 (0.4- 1.2) 1.5 (0.9-3.3 4.7 (1.9-5.9)

0.8 (0.7-1.4) 1.2 (0.8-3.2) 3.1 (1.1-5.7)

3.0 (1.6-4.6)

2.1 (1.5-3.1) 4.5 (2.6-5.3) 7.3 (4.7-8.6)

8.7 (3.9-11.1)

7.5 (4.0-9.4) 8.1 (5.0-nr) nr (6.6-nr)

4 (2.6-6)

10.1 (6.5-nr) nr (10-nr)

7 (4.8-9.2)

OS [years]