Brain Tumours

Efficacy outcomes – across trial

RTOG 9402 2 EORTC 26951 1

NOA-04

RT PCV+RT RT RT+PCV

RT

CT

PFS, IDHwt/1p/19 q intact OS, IDHwt/1p/19 q intact PFS, 1p/19q codel

1.0

1.2

0.6

0.8

0.8

0.8

2.7

2.6

1.8

2.1

4.7

3.1

2.9

8.4

4.2

13.1

8.7

7.5

OS, 1p/19q codel

7.3

14.7

9.3

Not reached

Not reached

Not reached

1. van den Bent et al. J Clin Oncol 2013 2. Cairncross et al. J Clin Oncol 2013