Brain Tumours

42 year old patient with MGMT methylated GBM, >90% resection, RT- TMZ. Recurrent, inoperable disease 14 months after completing adjuvant TMZ; PS=1. I would recommend:

A. TMZ rechallenge, 5/28 day schedule B. TMZ rechallenge, 21/28 day schedule C. PCV D. TMZ + bevacizumab E. Bevacizumab + irinotecan