Brain Tumours

61 year old patient with MGMT unmethylated GBM, >90% resection, RT-TMZ. Recurrent, inoperable disease 5 months after completing adjuvant TMZ; PS=1. I would recommend:

A. TMZ rechallenge, 5/28 day schedule B. PCV C. TMZ + bevacizumab D. Bevacizumab + irinotecan E. Best supportive care