Brain Tumours

Reduced dose Cranio Spinal Irradiation with CT

 65 “Standard-Risk” patients:  RT doses Craniospinal: 23.4 Gy Posterior fossa: 55.2 Gy

 Concomitant CT: weekly Vincristine  Adjuvant CT: Vincristine CCNU Cisplatin

PFS

“These overall survival rates compare favorably to those obtained in studies using full-dose radiation therapy alone”

Packer, J Clin Oncol 1999; 17:2127-36