Brain Tumours

Medulloblastoma- Randomised studies of CSI RT dose

POG 8631/CCG 932 (1986-1990)

- 23.4 Gy – 52 % 5 year EFS - 36 Gy – 67 % 5 year EFS - p 0,08 (trial stopped for an increased risk of isolated neuraxis failure)

- 23.4 Gy – 52 % 8 year EFS - 36 Gy – 60 % 8 year EFS - p 0,141