Brain Tumours

BRAFV600 Mutations in Pediatric Tumors • ~60% papillary thyroid carcinoma 1 • ~60% Langerhans cell histiocytosis 2 • ~50% melanoma 3,4 • ~10% Low grade gliomas – ~10% fibrillary astrocytoma, pilocytic astrocytoma 5 – ~60% pleomorphic xanthoastrocytoma 6 – ~60% gangliogliomas 7 • ~10% malignant astrocytomas 8

1 . Henke LE, et al. Pediatr Blood Cancer 2014;61:1168–1172;. 2 Badalian-Very G, et al. Blood 2010;116:1919–1923; 3 .Daniotti M, et al. J Invest Dermatol 2009;129: 1759–1768; 4 . Lu C, et al. J Invest Dermatol 2015;135:816–823; 5 . Bergthold G et al. Neuro Oncol 2015;pii:nov045; 6 . Dias-Santagata D, et al. PLoS One 2011; 6:e17948; 7 . MacConaill LE, et al. PLoS One 2009; 4:e7887; 8 . Nicolaides TP, et al. Clin Cancer Res 2011;17:7595-7604. 106