CPB Ljubljana 2018 course book

Main series with a combination of techniques

AUTHOR/ YEAR # patients/ # lesions

APPLICAT OR

# FRACTIO NS

DOSE (FR)

PRESCR PTION

TOTAL DOSE

FREQU ENCY

BED (Gy)

MEDIA N FOLLO W UP months

LOCAL CONTRO L

ACUTE TOXICI TY GRADE ≥ 3

CHRONIC TOXICITY

COMMENT S

Guix B et al. [17] 2000 136p

Brock applicator / customized molds Customized molds, Leipzig applicator Flap >3.5cm or irregular surfaces, Leipzig surf. appl Customized molds, Fleiburg flap, Interstitial

33-36

1.8 Gy 5mm from surface Orthogon al RX

60-65 Gy 75-80 Gy

Daily 70.1- 76.5

-----

97.8% Radical 99% Adjuvant 87% 93.4% (5 years)

10% 0%

Cosmesis excellent/ good 98%

T>4cm boost 10

Arenas M et al. [28] 2015 114p/134 Ghaly M et al. [35] 2008 55p/67

15-18 BCC

3 Gy 3-5 mm from skin surface

45-54 Gy

3 times week

58.5- 70.2

33

40.4% G3, 2.2% G4

0.8% G4 Cosmesis excellent or good 82%, Fair 13%

15-19 SCC

45-57 Gy

58.5- 74.1

8

5 Gy V

95 PTV (CT in Flap) Leipzig appropiat e depth

40 Gy Twice a week

60

18

95,5% 0% -----

Cosmesis excellent 95.5%

Rodríguez- Villalba 2003 /2007/2009 unpublished 67p/74

10

3 Gy

CTV (CT) 30 Gy

Twice a day/ 5 days

39

38

96% 10% Hipopigmen tation 1.3%

US to define depth and applicator

4-4.5 Gy (≥ 3 cm)

40-45 Gy

56-65.3