CPB Ljubljana 2018 course book

Results with Leipzig and Valencia applicators

AUTHOR/ YEAR # patients/ # lesions

APPLIC ATOR

# FRA CTIO NS

DOSE (FR)

PRESCR PTION

TOTAL DOSE

FREQU ENCY

BED (Gy)

MEDIAN FOLLOW UP (months)

LOCAL CONTROL

ACUTE TOXI-

CHRONIC TOXICITY

COSMETI C RESULT

CITY G ≥ 3

Kohler-Brock et al. [26] 1999 520 Ghaly M et al. [35] 2006 20p/21 Gauden S et al. [27] 2013 85p/92 Tormo A. et al. [33] 2014 32p/45 Delishaj D et al. [34] 2015 39p/57

Leipzig 4-8 5-10 Gy

30-40 Gy

Once- twice a week

91%

0%

Leipzig 8 5Gy Surface 40 Gy Twice a week

60.0 18

90.4% (lesions)

0% -----

excellent 90.4%

median

Leipzig 12 3 Gy appropi ate depth

36 Gy Daily 46.8 37

97% 0% Hipopig- mentation 11%

excellent/ good 88%

median

Valenci a

6-7 7-6 Gy 3-4 mm 42 Gy Twice per week

70 47

98%

Valenci a

8

5Gy

40 Gy 50 Gy

2-3 times week

60

12

96.2% Complete response

0% 19.3% G1-G2

Excellent 86% Fair 2.3%

10

5Gy

75