Course book Advanced Treatment Planning 2018

Clinical evaluation: comparison of toxicity data from different protocols

• Biologically Effective Dose

▪ A parameter that is independent from the fractionation ▪ It doesn’t express a real delivered dose

D D

d

D BED

= d

+ +



/



+



/



2

1

1

=

2

1

d



/



0

+



/



1

2

1

  

 

  

  

d D BED

d

1

1

 = dN

=

+

1

+

1

3

1

1



/





/



N : fraction number d 1 : fraction number

/ : alfa-beta ratio

for the given effect