Dose Course 2018_Flipping book

Non-targeted effects of IR

• Recent shift in

conventional paradigm of radiobiology

Radiation

• Targeted vs Non- targeted effects • Non-Targeted effects

Nucleus

GJIC

– Bystander effects (RIBE)

• Abscopal = clinical manifestation – Genomic instability (RIGI) – Low dose hypersensitivity – Adaptive response • Occur >0.5Gy IR

Cell - cell communication

Secreted Factors

Courtesy of Orla Howe, DIT