ESTRO 2021 Abstract Book

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ESTRO 2021

PO-1506 Psychological impact of COVID 19 pandemic in cancer patients: a cross sectional observational study

B. SANTO 1 , A. DI DONATO 1 , F. GIANNETTI 1 , I. RIDOLFI 1 , E. IPPOLITO 1 , S. RAMELLA 1 1 UNIVERSITA' CAMPUS BIO-MEDICO DI ROMA, Radiation Oncology, ROME, Italy

Purpose or Objective On 30 January 2020,WHO declared the outbreak of coronavirus disease 2019(COVID19).As cancer patients are already considered at increased risk of persistent depressive and anxiety disorders, the aim of this study was to evaluate psycological impact of the COVID19 pandemic in these patients.Psychological counseling services were offered to patients who showed anxiety and stress above selected cut off levels. Materials and Methods All consecutive adult cancer outpatients between April and May 2020 were prospectively enrolled in this study and therefore received structured and validated ad-hoc questionnaires.Emotional distress was measured by means of visual scale.The structured questionnaire consisted of questions covering several areas such as knowledge and concerns about COVID19,the psychological impact of the COVID19 outbreak and mental health.Validated self-assessment questionnaires for the evaluation of psychological functioning and resilience skills were:1)Connor-Davidson Resilience Scale(CD-RISC-25) investigating five factors of resilience;2)Beck Depression Inventory-II(BDI-II)consisting of 21 items evaluating the severity of depression;3)State and Trait Anxiety Inventory(STAI-¬TRAIT-Y) investigating the anxiety-trait and anxiety-state. Results A total of 208 patients completed the survey with a participation rate of 99%. Most of patients(79.3%) were in treatment and 20.7% in follow up.70 patients(42.7%) received palliation treatment and 94(57.3%) curative treatment. Patients who cohabited with others declared themselves to be more resilient; the COVID related physical concern is worse in those with lung cancer than in other cancers and in those on active treatment compared to follow up. COVID-related physical concern correlates significantly with depression, distress, and state and trait anxiety.

Conclusion During COVID19,depression and emotionality were limited in our patients.Physical concern,as expected due to the cancer diagnosis,was present in this cohort of patients and was higher in treatment compared with follow up patients.COVID19 worsens Trait-Anxiety in all patients. PO-1507 Clinical outcomes of bone stereotactic body radiotherapy in patients with oligometastatic cancer S.H.O. Jensen 1 , L. Nørgaard Bentzen 1 , E. Schjødt Worm 2 , M. Wang 3 , Y. Lassen-Ramshad 4 , S. Buus 1 1 Aarhus University Hospital, Department of Clinical Oncology, Aarhus, Denmark; 2 Aarhus University Hospital, Department of Medical Physics, Aarhus, Denmark; 3 Aarhus University Hospital, Department of Orthopedic Surgery, Aarhus, Denmark; 4 Aarhus University Hospital, Danish Centre for Particle Therapy, Aarhus, Denmark Purpose or Objective Stereotactic body radiotherapy (SBRT) for bone metastases in oligometastatic cancer patients is thought to increase progression free survival and improve overall survival. The purpose of this study was to retrospectively evaluate clinical outcomes of SBRT for oligo bone metastases in a single institution consecutive patient cohort, treated from 2015 to 2019 at Aarhus University Hospital. Materials and Methods Forty-six patients with a total of 54 metastases were included in the analysis. The most frequent primary diagnoses were prostate cancer, breast cancer, renal cancer, and lung cancer. SBRT was prescribed as the mean dose to the clinical target volume (CTV) with doses varying from 24 to 36 Gy in 3 fractions (n = 16 (24 Gy), n = 1 (25.5 Gy), n = 26 (27 Gy), n = 10 (30 Gy), n = 1 (36 Gy)). A PTV margin of 2-3 mm was applied. The PTV was covered by at least 80% of the prescribed dose, except for PTV regions overlapping with critical normal tissue (e.g. thecal sac). Treatments were delivered with VMAT guided by CBCT. Follow-up consisted of clinical examination, blood samples, and imaging with CT and/or MRI every three to six months. Patient information was retrieved from the patient records and the dose planning system. The endpoints were local