ESTRO 2021 Abstract Book

S1637

ESTRO 2021

Conclusion 3D models mimic the 3D structure of tissues and provide more predictive in vitro assays compared to cell cultures. They allow the control of testing conditions and the study of the effect of different agents. Models with microvasculature were produced, irradiated and assessed for the radioinduced damage. Further tests are planned to determine changes in permeability, perfusion, inflammation. Results will be used to tune a mechanistic computational model Funding: AIRC Investigator Grant, no. IG21479

Digital Poster: Radiobiology of stem cells (cancer and normal tissue)

PO-1919 Non-thermal plasma enhances the sensitivity to radiation in human colon cancer cells X. Zhu 1 , Y. Li 1 , Y. Liu 1 1 Peking University Shenzhen Hospital, Department of Radiation Oncology, Shenzhen, China

Purpose or Objective Radiotherapy is one of the main treatments for colorectal cancer, however, side effects and the resistance of tumor cells to ionizing radiation reduce the efficacy of radiotherapy. In recent years, non-thermal plasma (NTP) -an ionized gas which containing various reactive oxygen species (ROS), showed promising anticancer effect by selectively inducing oxidative stress to cancer cell while no obviously harmful to normal cells. In this study, we aimed to use this novel technique to investigate the radiosensitization effect and its potential mechanisms of NTP on colorectal cells. Materials and Methods Six kinds of colorectal cancer cells (SW480, SW620, HT-29, LOVO, HCT116, Caco-2) and one normal human colon mucosal epithelial cell line (NCM460) were applied in this study. The radiation-sensitivity and anti-proliferation effects of NTP on