ESTRO 2021 Abstract Book

S305

ESTRO 2021

De Tommaso 7 , C. Tamburella 8 , R. Di Franco 9 , S. Cossa 10 , V. Fusco 11 , A. Bianculli 11 , P. Ziccarelli 12 , L. Ziccarelli 12 , L. Caravatta 13 , D. Genovesi 14 , F. Deodato 15,16 , F. Fiorica 17 , G. Napoli 17 , M. Maltoni 18 , R. Rossi 18 , A.G. Morganti 4 , A.G. Morganti 2 1 Radiation Oncology , IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna , Italy; 2 Department of Experimental, Diagnostic, and Specialty Medicine - DIMES, Alma Mater Studiorum Bologna University, Bologna , Italy; 3 Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC di Radioterapia, Dipartimento di Scienze Radiologiche, Radioterapiche ed Ematologiche, Roma , Italy; 4 Radiation Oncology, IRCCS Azienda Ospedaliero- Universitaria di Bologna, Bologna , Italy; 5 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma , Italy; 6 Radiation Oncology, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy; 7 Radiation Oncology, General Hospital "Perrino", Brindisi, Italy; 8 U.O. di Radioterapia , AOOR PAPARDO PIEMONTE, Messina, Italy; 9 S.C. di Radioterapia , Istituto Nazionale Tumori Pascale, Napoli, Italy; 10 Radioterapia Opera di S. Pio da Pietralcina, Casa Sollievo della Sofferenza, San Giovanni in Rotondo, Italy; 11 Radiation Oncology, IRCCS CROB, Rionero in Vulture, Italy; 12 U.O. Radioterapia Oncologica , S.O. Mariano Santo, Cosenza, Italy; 13 Radioterapia , Università degli Studi G. D’Annunzio, Chieti, Italy; 14 Radioterapia, Università degli Studi G. D’Annunzio, Chieti, Italy; 15 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy; 16 Radiation Oncology Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy; 17 U.O.C.di Radioterapia e Medicina Nucleare, Ospedale Mater Salutis di Legnago, Verona, Italy; 18 IRCCS, Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy Purpose or Objective Inadequate treatment of pain is frequent in cancer patients (pts). Furthermore, studies on the adequacy of analgesic medication during Radiotherapy (RT) are lacking. The aim of this multicentric observational prospective trial was to evaluate the analgesics prescriptions in RT Departments (Dept), using the Pain Management Index (PMI). Moreover, we analyzed the correlation of PMI with pain characteristics and other potentially predictive factors. Materials and Methods Two thousand one hundred four pts were enrolled in 13 RT Dept and data on gender, age, intensity of pain measured with the Numeric Rating Scale (NRS), type of pain (cancer pain-CP, no cancer pain-NCP, mixed pain- MP), analgesics score, RT aim, ECOG Performance Status (PS), and tumor stage were collected. A Pain Score was defined with values between 0 (no pain; NRS: 0) and 3 (severe pain; NRS: 7-10). An Analgesic Score was defined with values between 0 (no pain medication) and 3 (use of strong opioids). PMI was calculated by subtracting the pain score from the analgesic score. A negative value of PMI indicates an inadequate analgesic prescription. This study was approved by the Ethical Committee of participating centers ( ARISE-1 study). Results Median age of patients was 64 years and 64.3% of pts (1353) had pain (CP: 30.7%, NCP: 21.7%; MP: 12.4%). PMI was < 0 in 30.4% and ≥ 0 in 69.6% of pts with pain. CP was correlated to higher NRS than NP and MP (p <0.001). Pts with CP and MP had more adequate analgesics prescription than NCP pts (p <0.001). Higher NRS values were correlated to worse PS in all the pts categories (p <0.001). Instead, in pts with CP and NCP a worse PS correlated with better PMI value (p< 0.001 and p = 0.034, respectively). At univariate analysis, higher pain intensity was more frequent in pts with metastatic disease (p <0.001), receiving palliative RT treatment (p <0.001), and with poor PS (p <0.001). A lower adequacy of analgesic prescription (PMI <0) was more frequent in women (p <0.001), and non-metastatic (p <0.001), receiving curative RT (p <0.001), and with better PS pts (p <0.001). ( Table 1 )