ESTRO 2022 - Abstract Book

S1235

Abstract book

ESTRO 2022

Conclusion According to recent studies, incorporating measurements of frailty in clinical trials is important to reduce the risk of worse outcomes. In our experience, preliminary results confirmed that Geriatric 8 questionnaire represents a simple tool to identify frail patients in daily practice. Although this study is still ongoing, the support of a multidisciplinary approach in vulnerable patients resulted useful in order to obtain their compliance to the treatment without increased toxicity.

PO-1456 Predictive toxicity markers in elderly patients underwent RT and managed by an oncogeriatric model

L. Caravatta 1 , L. Gasparini 2 , M. Taraborrelli 1 , M. Borgia 3 , M. Candeloro 4 , I. Bottone 5 , E. Porreca 6 , D. Genovesi 7

1 SS. Annunziata Hospital, “G. D’Annunzio” University, Department of Radiation Oncology, Chieti, Italy; 2 SS. Annunziata Hospital, “G. D’Annunzio” University, Department of Radiation Oncology, Chieti, Italy; 3 SS. Annunziata Hospital, “G. D’Annunzio” University , Department of Radiation Oncology, Chieti, Italy; 4 “G. D’Annunzio” University , Department of Medicine and Ageing Science, Chieti, Italy; 5 SS Annunziata Hospital, General Medicine 2 Unit, Chieti, Italy; 6 “G. D’Annunzio” University, Department of Medical, Oral and Biotechnological Science, Chieti, Italy; 7 “G. D’Annunzio” University , Department of Neuroscience, Imaging and Clinical Sciences, Chieti, Italy Purpose or Objective A growing number of elderly patients every year is treated with radiation therapy (RT), but little is known about side effects and outcome of irradiation in this potentially frail population. The identification of predictive factors of toxicity and frailty could offer a personalized treatment approach, thanks also to a multidisciplinary management of patients with increased risk of adverse outcomes. In this study we investigated the correlation of patient parameters with acute toxicities in elderly aged > 75 years treated with curative RT. Materials and Methods A prospective observational study was designed in our Center for patients with > 75years, candidate for curative RT. To these patients the radiation oncologist submitted the Geriatric 8 questionnaire (G8q) before and at the end of RT. Patients with G8 score < 14 were then evaluated by a multidimensional geriatric assessment, investigating cognitive (MMSE, GDS), functional (ADL, IADL, Tinetti) and nutritional (MNA short) domains, to define the frailty phenotype. In this setting, we retrospectively analyzed parameters like body mass index (BMI), number of comorbidities, total blood count, neutrophil