ESTRO 2022 - Abstract Book

S612

Abstract book

ESTRO 2022

Monday 9 May 2022

Teaching lecture: Rationale for microbiota-centered interventions in I-O and radiotherapy

SP-0675 Rationale for microbiota-centered interventions in I-O and radiotherapy

Z. Laurence 1 , D. Eric 2

1 gustave Roussy, Immunology, Villejuif, France; 2 gustave Roussy, Inserm Saclay, Villeuif, France

Abstract Text The cancer-immune dialogue subject to immuno-oncological intervention is profoundly influenced by micro-environmental factors. Indeed, the mucosal microbiota - and more specifically the intestinal ecosystem - influences systemic immunity, metabolism, the inflammatory tone and the fitness of the epithelial barrier, culminating in keep in in check cancer immunosurveillance and the clinical benefit of immunotherapy. Several pro-and retro-spective studies and meta-analyses, indicated that antibiotics blunt the efficacy of immune checkpoint inhibitors. Importantly, pioneering studies brought up the proof-of-principle that fecal microbial transplantation can possibly restore responsiveness of ICI-resistant melanoma. This talk will review the yin and yang of intestinal bacteria at the crossroads between the intestinal barrier, metabolism, and local or systemic immune responses during anticancer therapies. I will discuss diagnostic tools to identify gut dysbiosis and the future prospects of microbiota-based therapeutic interventions. The results of the impact of the taxonomic composition of intestinal commensals from the SABR study conducted at Gustave Roussy will be unveiled.

Teaching lecture: Modern imaging in radiation oncology

SP-0676 PET imaging

U. Nestle

Germany Abstract not available

SP-0677 MR imaging

V. Plodek University Hospital Carl Gustav Carus, Institute for Diagnostic and Interventional Radiology, Dresden, Germany

Abstract Text High-quality imaging is the basis for modern treatment planning in radiation oncology.

MR imaging has emerged as the key modality in the diagnosis and staging for many malignancies like rectal or prostate cancer. Due to its superior soft tissue contrast it is ideally suited for local tumor staging and re-staging, including the assessment of invasion of adjacent organs as well as lymph node staging. Several factors have to be taken into account in order to achieve excellent MR imaging quality, including patient preparation, ongoing teaching for doctors and technicians and optimization of imaging protocols.

The aim of this lecture is to give an overview on how to perform and interpret modern MR imaging.

Teaching lecture: Biomarkers guiding dose de-escalation in HNSCC

SP-0678 Biomarkers guiding dose de-escalation in HNSCC

N. Riaz

USA Abstract not available

Teaching lecture: U-Net for dummies

SP-0679 U-Net for dummies

F. Maes

Belgium Abstract not available