ESTRO 2022 - Abstract Book

S749

Abstract book

ESTRO 2022

Conclusion Para-aortic lymph nodes and lungs are the most common sites of SR. Nodal status at diagnosis, histologic subtype and large CTV HR at IGABT are the most important risk factors for the occurrence of SR. Patients with presence of one or more of these factors should be considered in future trials investigating the role of adjuvant treatment after primary chemoradiation.

OC-0831 Results of ARTIX phase III study: adaptive radiotherapy versus standard IMRT in head and neck cancer

J. Castelli 1 , K. Benezery 2 , A. Hasbini 3 , B. Gery 4 , A. Berger 5 , X. Liem 6 , S. Guihard 7 , S. Chapet 8 , S. Thureau 9 , P. Auberdiac 10 , P. Pommier 11 , J. Thariat 12 , B. Campillo 13 , R. de Crevoisier 14 1 Centre Eugene MArquis, Radiotherapy, Rennes, France; 2 Centre Antoine Lacassagne, Radiotherapy, Nice, France; 3 Clinique Pasteur Lanroze , Radiotherapy, Brest, France; 4 Centre François Baclesse, Radiotherapy, Caen, France; 5 CHU poitiers, Radiotherapy, Poitiers, France; 6 Centre Oscar Lambret, Radiotherapy, Lille, France; 7 Centre Paul Strauss, Radiotherapy, Strasbourg, France; 8 CHU Tours, Radiotherapy, Tours, France; 9 CLCC Rouen - Becquerel, Radiotherapy, Rouen, France; 10 Clinique Médico- Chirurgical et Obstétrical Claude Bernard, Radiotherapy, Albi, France; 11 Centre Léon Bérard , Radiotherapy, Lyon, France; 12 Centre Baclesse, Radiotherapy, Caen, France; 13 Centre Eugene Marquis, Clinical investigations, Rennes, France; 14 Centre Eugene Marquis, Radiotherapy, Rennes, France Purpose or Objective Patients with stage III or IV with LAOC treated with chemoradiotherapy were randomly assigned to standard radiotherapy or systematic weekly replanning (ART). Primary endpoint was salivary flow measured at 12 months using parafilm stimulation. Secondary outcomes were overall survival, local control, scintigraphic assessment of salivary function and patient reported outcomes (PROM) (Eisbruch Xerostomia-specific questionnaire, MDASI-HN). The ARTIX trial is a randomized multicentric study comparing a systematic weekly replanning (ART) with a standard IMRT for patients with a locally advanced oropharyngeal cancer (LAOC), with the aim of improving salivary function. Materials and Methods Patients with stage III or IV with LAOC treated with chemoradiotherapy were randomly assigned to standard radiotherapy or systematic weekly replanning (ART). Primary endpoint was salivary flow measured at 12 months using parafilm stimulation. Secondary outcomes were overall survival, local control, scintigraphic assessment of salivary function and patient reported outcomes (PROM) (Eisbruch Xerostomia-specific questionnaire, MDASI-HN). Results A total of 132 patients were assigned to the experimental arm (n=67) or standard arm (n=65). The salivation flow measured using parafilm stimulation at 12 months was 630 mg/min in the experimental arm and 584 mg/min in the standard arm (p=0.6) (Figure 1). A significant difference was found regarding excretory function of the parotid gland with scintigraphy, with a mean value of 48 % in the experimental arm compared to 41% in the standard arm (p=0.015). No significant difference was found regarding overall survival, local control and patient reported outcomes (Figure 2 : Evolution of Eisbruch score by arms)