ESTRO 2023 - Abstract Book

S304

Sunday 14 May 2023

ESTRO 2023

Results From year 2009 to 2018 in Taiwan, a total of 277 NPC patients with subsequent stroke were identified. The average age of stroke patients with NPC was 61.7 years old. Male predominance was observed (F:M = 1:4). The main type of stroke was infraction (77.6%), followed by transient ischemic attack (TIA), intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), which was not distributed differently from stroke patients without NPC. The TOAST classification of post-RT ischemic stroke in NPC patients revealed large artery atherosclerosis as the primary etiology, which was statistically higher compared to stroke patients without NPC (36.3% and 26.4%, respectively; P-value < 0.001). The area of infarction (anterior or posterior circulation) was not statistically different between NPC and non-NPC stroke patients. Table 1. Cohort characteristics

Conclusion We discovered a 10% statistically significant increase in large artery atherosclerosis as the main etiology of ischemic stroke in NPC patients based on the nationwide database analysis. This study may help physicians more accurately evaluate the risk and treatment of ischemic stroke in NPC patients. PD-0403 Systematic review of NTCP models for radiation-induced toxicities in head and neck cancer M. Tambas 1 , T. Takada 2,3 , E. Clementel 4 , A.M. Leeuwenberg 5 , M. Sharabiani 4 , J.A. Damen 6 , Z. Dunias 2 , J.F. Nauta 1 , K.G. Moons 7 , J.A. Langendijk 1 , E. Schuit 2 1 University of Groningen, University Medical Center Groningen, Department of Radiation Oncology, Groningen, The Netherlands; 2 Utrecht University, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands; 3 Fukushima Medical University, Shirakawa Satellite for Teaching And Research (STAR), Department of General Medicine, Shirakawa, Japan; 4 European Organisation for Research and Treatment of Cancer (EORTC), Headquarters, Brussels, Belgium; 5 Utrecht University, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands; 6 Cochrane Netherlands, Utrecht University, University