ESTRO 2023 - Abstract Book

S1160

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ESTRO 2023

Conclusion For our patient group outcomes are related to established prognostic factors (stage, grade, age and histology). Our cohort met the PORTEC-3 entry criteria however patients received adjuvant sequential chemotherapy followed by adjuvant radiotherapy. The majority of patients that recurred had metastatic disease at time of their first recurrence. Lone local recurrence rates were low. It will be important to see the impact of molecular sub classification on risk stratification.

PO-1434 HAPPY protocol impact on psychological well-being in patients with gynecological cancer

V. Lancellotta 1 , L. Dinapoli 2 , S. Mancini 3 , A. Salvati 3 , P. Cornacchione 2 , G.F. Colloca 2 , M. De Angeli 4 , B. Fionda 2 , G. Macchia 5 , S. Scalise 2 , M.A. Gambacorta 2 , L. Tagliaferri 2 1 Fondazione Policlinico Gemelli IRCCS, Radiation Oncology, Rome, Italy; 2 Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy; 3 Università Cattolica del Sacro Cuore, Radiation Oncology, Rome, Italy; 4 Università di Roma Tor Vergata, Radiation Oncology, Rome, Italy; 5 Gemelli Molise Hospital – Università Cattolica del Sacro Cuore, Radiation Oncology Unit, Campobassso, Italy Purpose or Objective Providing information in line with patients’ needs is an important determinant for patient satisfaction and might also affect, distress, anxiety and depression levels of cancer survivors. HAPPY protocol (Humanity Assurance Protocol in interventional radiotheraPY) defined the needs of patients undergoing interventional radiotherapy (IRT, also called brachytherapy) for gynecological cancer. This study assessed the effectiveness of 8 suggestions/interventions for enhancing the patient's psychological wellbeing throughout IRT. Materials and Methods Patients with gynecological cancer (endometrial and cervical cancer) undergoing IRT-HDR were included into the study. Three questionnaries were completed by patients both before and after IRT (T0 and T1): the Distress Thermometer (DT, a self-reported international standardized tool using a 0-to-10 rating scale); the Numerical Rating Scale (NRS), which allows patients to rate their discomfort throughout an IRT procedure by assigning a value between 0 and 10; the Hospital Anxiety and Depression Scale (HADS, a well validated and reliable self-reported measure designed to identify the presence and severity of anxiety and depression in cancer patients). During the IRT-HDR procedure was applied the HAPPY protocol. Results Fifty-five patients affected by gynecological cancer (42 endometrial, 13 cervical cancer) and treated with high-dose-rate (HDR)-IRT were selected from January to May 2022. The median age was 64 (range, 35-84) years. According to the International Federation of Gynecology and Obstetrics 2018, the majority of patients have Stage I endometrial cancer (29/42) and all patients with cervical cancer have a locally advanced stage (IB3-IVA).Most of patients have high education (51 patients, 92.7%) and are married or living with partner (38 patients, 69%). Only 14 patients (25.45%) are currently working. The HADS, DT and NRS average before IRT were 13.14, 4.58 and 5, respectively. The HADS, DT and NRS average after IRT and HAPPY protocol delivery were 12.31, 3.87 and 3.25, respectively. A Wilcoxon signed rank test analysis comparing T0 vs T1 scores showed a significant improvement in DT (p=0.0251), NRS (p< 0.00001) and HADS (p=0.034)