ESTRO 2023 - Abstract Book

S1161

Digital Posters

ESTRO 2023

(Table1).

Conclusion Interventional radiotherapy can be perceived as a stressful experience causing anxiety and distress for most women. The emotional state of patients undergoing IRT can be improved by adhering to clear interventions/recommendations provided before IRT, which are effective and affordable adjuncts, with the cooperation of an integrated, interdisciplinary team, and can be a positive predictor for psychological outcome.

PO-1435 Pretreatment Platelet-to-Lymphocyte Ratio as a Prognostic Factor for Cervical Cancer

F.A. Lima Aires 1 , L. Salgado 2 , L. Trigo 3 , L. Carvalho 4

1 Centro Hospitalar Universitário São João, Radiotherapy, Porto, Portugal; 2 Instituto Português de Oncologia , Radiotherapy, Porto, Portugal; 3 Instituto Português de Oncologia, Brachytherapy, Porto, Portugal; 4 Instituto Português de Oncologia, Radiotherapy, Porto, Portugal Purpose or Objective We analyzed the prognostic significance of pretreatment serum platelet-to-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), hemoglobin (Hg) and squamous cell carcinoma antigen (SCC) affecting the progression-free survival (PFS) and overall survival (OS) in cervical cancer patients treated with definitive chemoradiotherapy (CRT). Materials and Methods The clinical data of 170 patients that were treated with definitive CRT was retrospectively analyzed. The inclusion criteria were cervical cancer patients treated for curative intent who were receiving concurrent CRT. Patients with diseases that could affect the lymphocyte and platelet levels, such as chronic inflammatory disease, distant metastasis or other malignancies, and patients who were undergoing a hysterectomy were excluded. The prognostic factors for OS and PFS were investigated according to cut-off values determined by receiver operating curve analyses. Results At a mean follow-up time of 41.6 months (stand variation 20 months), the 5-year OS and PFS rates were 96.3% and 85.6%, respectively. Median pretreatment serum PLR, NLR, hemoglobin (Hg) and SCC were 133.46, 2.42, 12.75g /dl and 3.14 ng/mL, respectively. The optimal cut off points were 166.3 for PLR with area under the curve (AUC) of 0.596 (p = 0.189); 3.21 for NLR with AUC of 0.505 (p=0.955); 11.5 g/dl for Hg with AUC of 0.568 (p=0.621), and 3.8 ng/mL for SCC with AUC of 0.576 (p=0.346). In univariate analysis, pathology type and Hg were significant prognostic factors for OS and PLR and SCC for PFS. In multivariate analysis, PLR was significant prognostic factor for PFS. No prognostic factors were found for OS.