ESTRO 2023 - Abstract Book

S1302

Digital Posters

ESTRO 2023

Amyotrophic lateral sclerosis (ALS) is a disease characterized by progressive degeneration of motor neurons. One of the frequent symptoms is sialorrhea caused by progressive weakness. The aim of this retrospective study is to describe our experience and demonstrate the efficacy of radiotherapy in these patients. Materials and Methods This study included patients with ALS evaluated in a Radiation Oncology department from 2016 to 2021. We included patients older than 18 years, diagnosed with ALS and severe sialorrhea that had not responded to previous medical treatment were included. Underage patients and patients who did not tolerate positioning of the treatment were excluded. Results A total of 20 patients were included, 12 had bulbar ALS and 8 had spinal ALS. AIl patients underwent radiotherapy treatment on the parotid glands with 3D technique and 6MV photons in a single fraction of 7.5Gy. Satisfaction index score (SIS): 0-10 were asked in each patient to measure effectiveness. 15 (75%) patients reported a decrease in sialorrhea of more than 50% (SIS: 5). 5 (25%) patients presented poor responses to radiotherapy treatment. so re-irradiation with the same dose was performed with improvement in symptoms in half of these patients. The treatment was well tolerated, no patient presented grade >3 toxicity. Conclusion A single fraction of 7.5Gy is an effective and safe treatment in patients diagnosed with ALS with sialorrhea who do not respond to medical treatment.

PO-1604 Impact of COVID-19 pandemic in our Radiation oncology department

P. Valencia Nieto 1 , M. Herrera Román 1 , M. Sánchez Belda 1 , A.M. Cabezas Mendoza 1 , D. Miguel Pérez 1 , J.M. De Frutos Baraja 1 , A. Casado Camacho 1 , R. Jaraiz Diaz 1 , P. Alonso Martínez 1 , P. Diezhandino García 1

1 HCUV, Radiation Oncology, Valladolid, Spain

Purpose or Objective Radiotherapy is an effective palliative treatment for metastatic disease. The current COVID-19 pandemic has led us to consider shorter courses, new guidelines and prioritize cases clinically urgent. The purpose of this study is to analyze our practice in palliative treatment, new potential strategies and hypofractionation. Materials and Methods 252 patients who receive palliative Radiotherapy from March 2020 to March 2021 were reviewed. We analyze how the treatment line has been modified throughout the 1 year of the pandemic and other items related to the different therapeutic options as mortality, reirradiation, primary localization and intention. Results Median age was 68 years (range 33-95y), 66% males, 34% females. Main primary tumors were 30% lung, 12% prostate and 10% breast. 65% patients had painful bone metastases, 15% brain metastases, 14% cord compression, 4% bleeding and 2% superior vena cava obstruction. Advanced disease was detected in 12% as debut. Half of patients were treated in the two first months of the pandemic than later.

Treatment provided was:

8 patients required reirradiation. Currently, 66% died.

Conclusion Radiotherapy plays a critical role improving quality of life in patients with advanced disease, even in the midst of the COVID-19 pandemic. During the first months of confinement, short radiation therapy cycles prevailed over the long ones, as the normal schemes of fractionation coinciding with a greater number of sessions gained importance as time went on.

PO-1605 LATTICE radiotherapy: A one institution experience

I. Solero 1 , A. Ciafre 2 , J. Germain 1 , O. Prato 1 , M. Borras 1 , M.J. Perez-Calatayud 1 , F. Celada 1 , M. Berenguer 1 , A. Conde 1