ESTRO 2023 - Abstract Book

S1303

Digital Posters

ESTRO 2023

1 Hospital La Fe, Radiation Oncology, Valencia, Spain; 2 Hospital Clinico de Valencia, Radiation Oncology, Valencia, Spain

Purpose or Objective LATTICE Radiotherapy (LRT) emerges as an innovative approach for treatment of voluminous tumors not suitable for resection. We aim to evaluate the tumor response and safety of this technique in a cohort of patients with bulky tumors treated in our institution. Materials and Methods A retrospective review of patients treated with LTR from March 2019 to April 2022 has been done. VMAT plans were employed in all cases and treatments were guided by CBCT on each fraction. RTOG scales of toxicity have been employed. Volume changes and necrosis of the bulky tumour were assessed. Results 14 patients with a mean age of 50 years (32 to 81) received LTR. Tumor volume ranged from 212cc to 7999cc with a median of 5 lattice vertices (2 to 13) manually placed within the GTV representing a median of 0.33% of its volume. Lung tumor was the most frequent primary (35%). 3 patients received a total dose (EQD2) >60Gy. Image evaluation post LRT was performed in 9 patients, showing volume reduction or necrosis in 7 patients, stability in 2. With a median follow-up of 3 months (2-37), no tumor lysis syndrome or grade 2-3 toxicity related to RTL was found. Conclusion LTR appears to be a safe modality to treat bulky tumors without significant morbidity directly related to RT treatment. Further develop of treatment protocols to standardize LTR are required. S.M. Christ 1 , K. Pohl 2 , J. Willmann 1 , P. Heesen 1 , M. Ahmadsei 1 , U.J. Muehlematter 3 , A. Kühnis 1 , E. Vlaskou Badra 1 , M. Mayinger 1 , P. Balermpas 1 , N. Andratschke 1 , M. Huellner 3 , M. Guckenberger 1 1 University Hospital Zurich, Department of Radiation Oncology, Zurich, Switzerland; 2 Waidspital Zurich, Department of General Surgery, Zurich, Switzerland; 3 University Hospital Zurich, Department of Nuclear Medicine, Zurich, Switzerland Purpose or Objective Definitions of oligometastatic versus polymetastatic disease vary, yet a cut-off of five solid organ metastases is frequently used for their differentiation. The benefit of definitive local therapy in metastatic cancer patients might not optimally captured in such a binary model, but may – in analogy to the spectrum theory of metastasis – rather vary gradually along the actual tumor burden and the associated risk of occult distant metastatic disease. The aim of this study is to examine metastatic patterns and quantify tumor burden in light of the spectrum theory of metastatic disease in a cohort of unselected metastatic cancer patients leveraging PET imaging reports. Materials and Methods Imaging reports from all oncological PET scans conducted at the Department of Nuclear Medicine of the University Hospital Zurich in 2020 were screened for this study. We identified PET scans from cancer patients and analyzed imaging reports of patients with metastatic disease. Number and sites of metastasis were extracted from imaging reports, and subsequently assessed leveraging descriptive summary statistics and Chi-squared test statistics to test for statistical associations between variables. Results In total, 7,000 PET scans were screened, of which 5,773 (82%) imaging studies were acquired in cancer patients and 5,358 (93%) in patients with solid malignancies. One third of PET scans (n=1,754; 33%), emanating from 1,155 unique patients, showed presence of metastatic disease. Of those, 601 (52%) and 554 (48%) were classified as oligometastatic (1-5 distant metastases) and polymetastatic ( ≥ 6 distant metastases), respectively. Analysis of the number of distant metastases showed a strong bimodal distribution of metastatic burden (Fig. 1). In patients, where number of metastases could be determined based on imaging report review (1,024/1,155; 88%), 26% of patients had one solitary metastasis and 33% of patients had >10 metastases. Yet, despite 33% of polymetastatic patients having >10 distant metastases, their pattern of distribution was restricted to one or two organs in the majority of patients, and there was no statistical association between the number of distant metastases and the number of involved organs in this patient cohort. Conclusion In conclusion, the majority of patients in this cohort had either a solitary metastasis or a very high tumor burden with >10 metastases, with the latter scenario often being associated with affecting a limited number of organs only. We interpret these findings as evidence in support of the spectrum theory of metastasis. The ongoing assessment of the addition of definitive local therapy for metastatic patients might indeed prove beneficial for selected patients along the whole metastatic spectrum. PO-1606 Metastatic tumor burden in cancer patients: implications for the oligometastatic spectrum theory