ESTRO 2024 - Abstract Book

S1113

Clinical - Gynaecology

ESTRO 2024

Abderahmane Mami hospital, Radiation oncology, ariana, Tunisia

Purpose/Objective:

Survival rates among gynaecological cancer patients have increased over time. However, patients must now deal with long-term treatment-related issues affecting their quality of life.The aim of this study was to assess quality of life (QoL) and correlate it with dose–volume parameters of organ at risks in patients receiving Volumetric modulated Arc therapy (VMAT) irradiation for gynecological cancer.

Material/Methods:

All patients treated with VMAT irradiation for gynecological cancers between September 2022 and October 2023 at the Department of Radiation Oncology, Abderrahman Mami Hospital were screened for this study. A total of 50 patients (31 with endometrial cancer, 17 with cervical cancer and 2 with vulvar cancer) were interviewed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), and its cervical cancer (EORTC QLQ-CX24), endometrial cancer (EORTC QLQ-EN24) or vulvar cancer (EORTC QLQ- VU34) module. QoL scores were classified as high, averge or low. Acute toxicity was graded with Common Terminology Criteria for Adverse Events.Bladder incontinence or urgency, rectal discomfort or abdominal pain and sexual functioning were investigated and correlated with dose–volume parameters of organs at risk.

Results:

The median age at diagnosis was 57 years [30-86 years]. Thirty-six patients (72%) received concomitant chemotherapy. Forty-eight percent of patients reported high QoL. The rate of high-grade bladder incontinence and bladder urgency was 28% and 46%, respectively. The rate of high-grade rectal discomfort and abdominal pain was 33.3%. Among the patients engaged in sexual activity, 44.4% experienced a dyspareunia.We found a significant correlation between bladder V40 (absolute percentage of bladder volume that received a dose of 40 Gy) and bladder urgency (p=0.008, R 2 = 0.38). We also found a significant correlation between rectum V40 (absolute percentage of rectum volume that received a dose of 40 Gy) and rectal discomfort (p=0.0001, R 2 =0.48).

Conclusion:

Our findings suggested that QoL during pelvic radiotherapy with VMAT technique has a an acceptable profile with minimal limitations of daily activities. In addition, QoL was correlated with dose–volume parameters. However, longer follow- up is required to better assess QoL profile.

Keywords: Gynecological cancer, quality of life

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Early response assessment of Ca cervix treated with PETCT based SIB-Online Adaptive Radiotherapy