ESTRO 2024 - Abstract Book

S1240

Clinical - Head & neck

ESTRO 2024

(eGFR ≥80 mL/min/1.73m2) of patients achieved a cumulative cisplatin dose of ≥200 mg/m2, respectively ( p <0.01, chi- square test). Upon multivariate logistic regression analysis with cumulative cisplatin ≥200 mg/m2 as the dependent variable, and ECOG, T stage, p16/HPV status, oropharynx tumor localization, eGFR, and baseline anemia as independent variables, p16/HPV positivity (OR=3.13, 95%CI 1.73-5.64, p <0.001), a higher eGFR (OR=1.04, 95%CI 1.02-1.06, p <0.001), and absent baseline anemia (OR=1.90, 95%CI 1.11-3.26, p <0.05) were predictive variables for a cumulative cisplatin dose of at least 200 mg/m2.

Conclusion:

Despite the importance of achieving a cumulative cisplatin dose of ≥200 mg/m2, a substantial proportion of older adults with HNSCC struggle to attain this critical threshold, with single-agent cisplatin emerging as a more feasible option. Knowledge about parameters influencing patients’ cisplatin tolerability might help clinicians developing individualized strategies to improve cisplatin tolerability, e.g., more intensive hydration regimens in patients with reduced kidney function. Based on these data, we aim to develop and validate a predictive model regarding cisplatin tolerability in older adults with HNSCC undergoing chemoradiation.

Keywords: Geriatric, chemotherapy

1015

Digital Poster

Inter-correlations between pathological prognostic features in resected buccoalveolar complex cancer

Parveen Ahlawat, Sarthak Tandon, Sandeep Purohit, Akash R Bellige, Gerim Prasai, Sauharda Lohani, Apoorva Nayak, Aslam Najeem, Munish Gairola

Rajiv Gandhi Cancer Institute and Research Centre, Radiation Oncology, New Delhi, India

Purpose/Objective:

Various histopathological features of prognostic significance are assessed in resected specimen of oral cavity cancers. However, all subsites of oral cavity may not necessarily have similar distribution of these features, hence there may not exist similar inter-correlations between these features. Few studies have evaluated these inter correlations however all these studies have included mixed populations of oral cavity subsites such as mucosal lip, buccal mucosa, gingiva, retromolar trigone, tongue, floor of mouth and hard palate. bucco-alveolar complex squamous cell carcinoma comprising of cancers originating from buccal mucosa, gingivo-buccal sulcus, gingiva and retromolar trigone, is a very common cancer in Indian subcontinent owing to the high prevalence of tobacco chewing habit. Despite being it common in this part of the world not much literature exist with regard to the pathological prognostic features and their inter-correlations in this complex site. The aim of this study was to study the distribution and extensive inter-correlations of various pathological features in resected specimen of bucco alveolar complex squamous cell carcinoma.