ESTRO 2024 - Abstract Book

S1241

Clinical - Head & neck

ESTRO 2024

Material/Methods:

A chart review was done for 180 patients with bucco-alveolar complex squamous cell carcinoma who underwent upfront resection of the primary tumour and neck dissection. Various pathological factors of proven prognostic importance were recorded in the resected specimen by the experienced head and neck onco-pathologist. Factors studied were pathological T stage, pathological nodal stage (N Stage), grade, lymphovascular invasion (LVI), perineural invasion (PNI), depth of invasion (DOI), tumour thickness (TT), worst pattern of invasion (WPOI), and extranodal extension (ENE). Inter-correlations were performed between various pathological factors using Spearman’s correlation test.

Results:

There were 9%, 19.1%, 30.3%, 40.4% and 1.1% patients with pT1, pT2, pT3, pT4a and pT4b stage respectively; 51.1%, 13.6%, 6.9 and 8% patients with pN0, pN1, pN2a and pN2b respectively; 6.7%, 92.1% and 1.1% patients with well differentiated, moderately differentiated and poorly differentiated grade respectively; 24.7% patients with PNI, 26% with LVI, 15.7%, 33.7% and 50.6% patients with DOI ≤5mm, >5 to 10mm and >10mm respectively; 9%, 70.8% and 20.2% patients with WPOI 3, 4 and 5 respectively; and 60.5% patients with ENE. pT stage has significant positive correlation with pN stage, DOI, PNI, TT and ENE. pN stage has significant positive correlation with PNI, LVI and ENE. Grade has no significant correlation with any other factors. PNI has significant correlation with DOI, LVI, TT and WPOI. LVI has significant correlation with pT stage, DOI, PNI, TT and WPOI. DOI has significant correlation with pT stage, PNI and TT. TT has significant correlation with pT stage, DOI, PNI, WPOI and ENE. WPOI has significant correlation with pT stage, pN stage, DOI, PNI, LVI and ENE. ENE has significant correlation with pT stage, pN stage, PNI and LVI. Many of these correlations are not shown in most other studies on oral cancer.

Various inter-correlation between factors found are shown in Table.

Factors

pT Stage pN Stage DOI

Grade

PNI

LVI

TT

WPOI

ENE

pT Stage -

Yes

Yes

No

Yes

Yes

Yes

No

Yes

pN Stage Yes

-

No

No

Yes

Yes

No

No

Yes

Grade

No

No

No

-

No

No

No

No

No

PNI

Yes

Yes

Yes

No

-

Yes

Yes

Yes

No

LVI

Yes

Yes

Yes

No

Yes

No

Yes

Yes

No

DOI

Yes

No

-

No

Yes

No

Yes

No

No

TT

Yes

No

Yes

No

Yes

No

-

Yes

Yes

WPOI

Yes

Yes

Yes

No

Yes

Yes

No

-

Yes

ENE

Yes

Yes

No

No

Yes

Yes

No

No

-

Conclusion: