ESTRO 2024 - Abstract Book

S1242

Clinical - Head & neck

ESTRO 2024

Various pathological prognostic features in resected bucco-alveolar complex squamous cell carcinoma are inter correlated. This information can be utilized for better prognostication and adjuvant treatment decision. There should be continued effort to identify new pathological features to give more insight into tumour biology.

Keywords: oral cancer, buccal cancer, pathological factors

1019

Digital Poster

Managing Squamous Cell Carcinoma of External Auditory Canal -a Single institution experience.

John Mohan Mathew 1,2 , Malu Rafi 1 , Lekha Madhavan Nair 1 , Kainickal Cessal Thomas 1 , Preethi Sara George 1 , Shaji Thomas 3 , Rejnish Ravi Kumar 1 1 Regional Cancer Centre, Radiation Oncology, Thiruvananthapuram, India. 2 Princess Margaret Hospital, Radiation Oncology, Toronto, Canada. 3 Regional Cancer Centre, Surgical Oncology, Thiruvananthapuram, India

Purpose/Objective:

External Auditory Canal (EAC) is a rare head and neck sub-site for occurrence of Squamous Cell carcinomas (SCC) and account for only around 0.2% of cancers of this region. There is limited literature available, pertaining to management of this rare malignancy. We report a retrospective study on a cohort of patients with SCC of EAC treated at a Tertiary Cancer Centre in South India. The aims of our study were to determine the treatment outcomes and factors affecting outcomes in patients diagnosed with SCC of EAC who were treated at the Institute.

Material/Methods:

We have retrospectively reviewed the case files of all patients with biopsy proven SCC of EAC treated at our Institute between 1st Jan 2005 to 31st Dec 2019. All patients were staged using AJCC-TNM criteria and re-staged as per the Modified Pittsburg criteria[1] and the NEW stage grouping proposed by George et al.[2]The primary objectives of our analysis were estimation of Overall Survival (OS) and Disease Free Survival (DFS) and the secondary objectives included patterns of failure and evaluating factors affecting survival. All analysis was done in SPSS v28 with DFS and OS being estimated using Kaplan-Meier method with log-rank test used for comparison and predictors of outcomes assessed using cox proportional hazards regression model.

Results:

A total of 39 patients were included in the study with a mean age of 55.5 years (SD=13) and 56% being female. The most common presenting symptom was discharge from ear (51.3%) followed by pain(41%) and swelling (38%).Nearly 2/3rd patients had CT/MRI for staging.7 patients (18.4%) presented with facial nerve palsy. 20 patients (51.3%) had stage I /II disease and 18 (46.2%) had stage III/ IV disease as per TNM composite staging criteria; When