ESTRO 2024 - Abstract Book

S1260

Clinical - Head & neck

ESTRO 2024

Conclusion:

An ideal palliative radiation regimen should be able to strike a balance between delivering adequate dose that is able to achieve durable local response and at the same time not exceed threshold for causing acute toxicity. This study showed that fractionation regimens that deliver higher EQD2 have more promising results when it comes to providing sustained and significant improvement in symptoms caused by advanced stage of disease in HNC. Although short, hypo-fractionated regimens are convenient to administer when seen from logistical point of view, they fall short in terms of degree of response at local site and poorer PFS as compared to their counterpart regimens delivering comparatively higher dose. Also, greater emphasis is required on navigating palliative patients with a multidisciplinary approach towards individualising treatment, with inclusion of appropriate systemic therapies and rehabilitative services.

Keywords: palliative, dose fractionation, survival

References:

1.Kulkarni MR. Head and neck cancer burden in India. International Journal of Head and neck surgery. 2014 Aug 1;4(1):29-35.

2.Grewal AS, Jones J, Lin A. Palliative radiation therapy for head and neck cancers. International Journal of Radiation Oncology* Biology* Physics. 2019 Oct 1;105(2):254-66.

3.Agarwal JP, Nemade B, Murthy V, Ghosh- Laskar S, Budrukkar A, Gupta T, D’Cruz A, Pai P, Chaturvedi P, Dinshaw K. Hypofractionated, palliative radiotherapy for advanced head and neck cancer. Radiotherapy and Oncology. 2008 Oct 1;89(1):51-6.

4.Williams GR, Manjunath SH, Butala AA, Jones JA. Palliative radiotherapy for advanced cancers: indications and outcomes. Surgical Oncology Clinics. 2021 Jul 1;30(3):563-80.

5.Porceddu SV, Rosser B, Burmeister BH, Jones M, Hickey B, Baumann K, Gogna K, Pullar A, Poulsen M, Holt T. Hypofractionated radiotherapy for the palliation of advanced head and neck cancer in patients unsuitable for curative treatment –“Hypo Trial”. Radiotherapy and Oncology. 2007 Dec 1;85(3):456 -62.

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Poster Discussion

Progressive decline in dental pulp sensitivity in oropharyngeal cancer treated with radiotherapy

Parveen Ahlawat 1 , Sarthak Tandon 1 , Mandeep S Grewal 2 , Nishtha Gupta 2 , Sandeep Purohit 1 , Akash R Bellige 1 , Sauharda Lohani 1 , Gerim Prasai 1 , Apoorva Nayak 1 , Aslam Najeem 1 , Munish Gairola 1