ESTRO 2024 - Abstract Book

S2910

Interdiscplinary - Other

ESTRO 2024

6. Kolata G. Popular Prostate Cancer Therapy Is Short, Intense and Unproven. N Y Times 2017 Mar 20; Available from: https://www.nytimes.com/2017/03/20/health/prostate-cancer-sbrt-radiation-therapy.html [accessed Jul 20, 2023]

1464

Digital Poster

Effects of nutritional counselling on management &clinical outcome in pelvic RT: observational study

Francesca Di Pressa 1 , Lorenzo Ientile 1 , Alessio Bruni 1 , Marco Vernaleone 1 , Roberto Sabbatini 2 , Silvia Gabriele 3 , Stefano Scicolone 1 , Cinzia Baldessari 2 , Maria Giuseppa Vitale 2 , Ercole Mazzeo 1 , Filippo Valoriani 3 , Chiara Bussei 3 , Renata Menozzi 3 , Massimo Dominici 2,4 , Frank Lohr 1 , Giuseppina De Marco 1 1 UOC Radioterapia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy. 2 UOC di Oncologia Medica, DAI di Oncologia ed Ematologia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy. 3 SSD Malattie del Metabolismo e Nutrizione Clinica, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy. 4 Laboratory of Cellular Therapy, Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Purpose/Objective:

A nutritional counselling service for patients undergoing pelvic radiotherapy (RT) was established and its impact on patient compliance with RT treatment as well as acute and late intestinal toxicity was evaluated within the framework of a prospective study. The aim of this abstract is also to compare the preliminary results with data regarding replanning CT frequency and number of necessary daily set-up evaluations reported in the literature and observed in a continuous cohort treated at our department in 2019 without interventions.

Material/Methods:

In this Ethics Committee-approved [CE1408/2020] monocentric observational pilot study, patients with age > 18 years, capacity to sign informed consent, women with gynecological cancer candidates for adjuvant RT or men with prostate cancer who were candidates for adjuvant or salvage RT to the prostate bed, PS ECOG 0-1, absence of contraindications to pelvic RT included. Nutritional counselling consisted of a preliminary visit within 5 days from the enrollment with nutritional instructions (based on the food diary compiled by the patients, reporting their prior nutritional habits). A treatment planning CT scan was scheduled at least ten days after the nutritionist intervention. Nutritional appointments were planned halfway through and at the end of RT. During the treatment, in case of inappropriate intestinal preparation, the radiation oncologist could schedule an additional nutritional consultation. Primary endpoint was the evaluation of the effect of tailored nutritional counselling on intestinal preparation and the consequent impact on patient management during RT. Compliance with nutritional counselling, number of repeated treatment planning CTs and set up evaluations with MVCT/CBCT were the primarily analyzed parameters. Data provided by Song et al. that reported a mean CBCT number per fraction of 1.43 and thus a number of 8 CBCTs in excess of a hypothetical 20-fraction series with > 2 CBCTs/fraction in 10% of patients may serve as an upper estimate benchmark in a cohort without any pre-CBCT-intervention (1). Acute and late toxicity > grade 2, scored with CTCAE v5.0, was evaluated as secondary endpoint.