ESTRO 2024 - Abstract Book


Clinical - Head & neck

ESTRO 2024

1 Far Eastern Memorial Hospital, Department of Radiation Oncology, New Taipei City, Taiwan. 2 Far Eastern Memorial Hospital, Department of Otolaryngology, Head and Neck Surgery, New Taipei City, Taiwan. 3 National Yang Ming Chiao Tung University,, School of Medicine, Taipei, Taiwan


The current study aims to evaluate the potential impact of modern radiotherapy (RT) techniques for patients with head and neck cancer in quality of life (QoL) with a longitudinal analysis.


In this single-center prospective study, participants were asked to fill out QoL questionnaires that include contents of EORTC QLQ-C30, QLQ-H&N 35 and utility score by time trade off (TTO) at three time points (2 weeks, 3 months and 6 months) after completion of RT. All patients treated by modern techniques (Volumetric modulated arc therapy, VMAT or helical tomotherapy, HT). Patients who developed recurrence or died before 6 month follow up were excluded.


From 2022 to 2023, a total of 45 patients were recruited. For those who completed surveys at 2 weeks with at least 1 time follow-up (30, 67%) were enrolled for final analysis. The majority in 30 patients were men (76.7%), oral cancer (40%), stage III or IV (60%), received surgical intervention (63%) and treated by chemoradiation (80%). A total dose of 66 to 70 Gy was delivered to 23 (76.7%) patients, half of them treated by HT. Patients received chemotherapy had significant lower scores in global QoL (mean difference, 27.94; 95% CI, 9.33-46.55). Global QOL, physical function, symptoms of sticky saliva, cough, feeling of illness and weight loss were improved significantly between the 2 weeks to 3 months, respectively. There was no significance between 3 to 6 months. Interestingly, improvement of social function, social contact, pain and nutrition reached significance at 6 months. Subgroup analysis showed greater relief of pain over time for those who applied HT (p=0.030). Moreover, decrease in nausea and vomiting events were more apparent in patients who joined swallowing rehabilitation programs (p=0.036).

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