ESTRO 2024 - Abstract Book

S1550

Clinical - Lower GI

ESTRO 2024

One-year, 3-years and 5-years OS rates were 94.9%, 63.8%, and 45.1%, respectively, with a median OS of 51.6 months. One-year, 3-years and 5-years LC were 79.4%, 67.8% and 67.8%, respectively. Median LC was not reached.

Factors associated with poorer OS were a worse performance status and a lesion dimension greater than 14.1 cc (median OS of 41.6 months, with respect to 68.5 months for smaller lesions).

A greater number of metastases and a biological effective dose (BED) lower than 105.6 Gy were negative predictive factors of LC.

Conclusion:

This retrospective study displayed the efficacy of SBRT in the treatment of oligomestastatic patients with colorectal cancer. Tumour volume and number of treated metastases are significant predictive factors of patient outcome. The results of this study provide valuable data to optimize radiation therapy treatments in this setting of patients.

Keywords: Colorectal cancer, Oligometastatic state, SBRT

References:

(1) Hellman S, Weichselbaum RR. Oligometastases. J Clin Oncol. 1995 Jan;13(1):8-10. doi: 10.1200/JCO.1995.13.1.8. PMID: 7799047.

(2) Biller LH, Schrag D. Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. JAMA.2021;325(7):669– 685. doi:10.1001/jama.2021.0106

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Digital Poster

Uterine transposition vs ventrofixation before radiotherapy as a fertility sparing option in young

ROSA AUTORINO 1 , MATTEO PAVONE 2 , NICCOLO' BIZZARRI 2 , Giuditta Chiloiro 1 , GIACOMO CORRADO 2 , MARIA GABRIELLA FERRANDINA 2 , GABRIELLA MACCHIA 3 , GIOVANNI SCAMBIA 2 , DENISE QUERLEU 2 , MARIA ANTONIETTA GAMBACORTA 1 1 4. UOC Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Radiotherapy, Rome, Italy. 2 3. UOC Ginecologia Oncologica, Dipartimento per la salute della Donna e del Bambino e della Salute Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Gynecology, Rome, Italy. 3 Radioterapia Oncologica, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Radiotherapy, Campobasso, Italy

Purpose/Objective:

(Chemo)radiation may be a required treatment in young women with pelvic malignancies. Irradiation may result in ovarian and uterine failure, compromising the fertility of those patients. While ovarian transposition is an