ESTRO 2024 - Abstract Book

S1599

Clinical - Lung

ESTRO 2024

significance was not achieved, apart from the reduction in RVEF%, when using the available data from 11 patients. LGE, T1 and T2 values did not change significantly between baseline and post treatment imaging. There was abnormal focal myocardial 18F-FDG uptake in the post-RT and 6 months post-RT scans in 4 patients (Figure 1) mainly in the basal inferior/inferolateral segments not present on the baseline scan. This was also reflected in the whole cohort by an increase in myocardial 18F-FDG uptake heterogeneity as suggested by a small increase in CoV from 0.16 at baseline to 0.19 ±0.05 post RT (p=0.07).

Conclusion:

To our knowledge, this is the first study to use cardiac PET/MRI to investigate systematically treatment-related early cardiac changes in adult cancer patients. Novel findings were a significant reduction in RVEF% of >10% in 35% of patients which was not anticipated and, to the best of our knowledge, has not been reported previously, and the abnormal focal 18F-FDG uptake observed in the myocardium. The abnormal 18F-FDG uptake may be a potential nidus for downstream myocardial fibrosis, however, long term follow-up is required to determine this and the impact on myocardial function. We also found significant, albeit small, absolute reductions in LV and RV end diastolic volumes and LVEF% following treatment. However, for some cases, the LVEF% decreased by a magnitude of greater than 10%, the relevant threshold for the initiation of cardioprotective therapy. We aim to confirm whether these changes persisted in the 6 months post-RT scans in the whole cohort once all scans are completed by the end of 2023.

Keywords: cardiotoxicity, multidisciplinary, cardio-oncology

References:

1. American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging:, Cerqueira, M.D., Weissman, N.J., Dilsizian, V., Jacobs, A.K., Kaul, S., Laskey, W.K., Pennell, D.J., Rumberger, J.A., Ryan, T. and Verani, M.S., 2002. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation, 105(4), pp.539-542. 2. Tahara, N., Tahara, A., Nitta, Y., Kodama, N., Mizoguchi, M., Kaida, H., Baba, K., Ishibashi, M., Hayabuchi, N., Narula, J. and Imaizumi, T., 2010. Heterogeneous myocardial FDG uptake and the disease activity in cardiac sarcoidosis. JACC: Cardiovascular Imaging, 3(12), pp.1219-1228.

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Digital Poster

Feasibility of a prehabilitation programme for radical radiotherapy treated lung cancer patients

Ewan Gourlay 1,2 , Zoe Merchant 3 , Corie Jackson 3 , John Moore 4 , Jack Murphy 5 , Patrick Goodley 3,2 , Sagar Vasandani 6 , Louise Brown 1 , Kathryn Banfill 7 , Matthew Evison 3