ESTRO 2024 - Abstract Book

S1600

Clinical - Lung

ESTRO 2024

1 Manchester University NHS Foundation Trust, Department of Respiratory Medicine, Manchester, United Kingdom. 2 University of Manchester, Division of Immunology, Immunity to Infection and Respiratory Medicine, Manchester, United Kingdom. 3 Manchester University NHS Foundation Trust, Manchester Thoracic Oncology Centre, Manchester, United Kingdom. 4 Manchester University NHS Foundation Trust, Division for Anaesthesia, Peri-Operative Medicine and Critical Care Services, Manchester, United Kingdom. 5 GM Active, Prehab4Cancer, Manchester, United Kingdom. 6 Christie NHS Foundation Trust, Greater Manchester Cancer Alliance, Mancheser, United Kingdom. 7 Christie NHS Foundation Trust, Clinical Oncology, Manchester, United Kingdom

Purpose/Objective:

Multimodality patient optimisation, commonly referred to as prehabiliation has been shown to offer meaningful physiological and clinical improvements for patients undergoing lung cancer surgery[1]. There is limited data as to feasibility and efficacy of prehabilitation in those undergoing radiotherapy for lung cancer. The Greater Manchester (GM) Prehab4Cancer (P4C) programme, expanded its services to incorporate patients undergoing radical intent radiotherapy for lung cancers in 2020. Here we analyse the outcomes of this new service.

Material/Methods:

Patients referred to the P4C service with non-surgical radically treatable lung cancer underwent personal assessment and intervention focused on exercise, nutrition and wellbeing. Exercise prescriptions were either home based or utilising a network of community leisure facilities. Service delivery outcomes were assessed against key performance indicators previously used for the surgical treatment cohort[2]. Demographics, treatment modalities and toxicities experienced during therapy were compared between groups who completed the P4C program and those who did not. Functional physiology was assessed via six-minute walk test (6MWT) and Sit to Stand test (STS). Quality of life was assessed via International Physical Activity Questionnaire (IPAQ), WHO Disability Schedule (WHODAS), Self-Efficacy for Exercise Scale (SEE) and Euro-Qol 5 Dimension (EQ-5D-5L). Assessments at initiation and completion of the programme were analysed using a paired T-Test (parametric data), Wilcoxon Signed rank (non- parametric data) and Pearson’s chi -squared (categorical data). Patients referred between 05/09/2019 to 30/09/2022 were included. A modified service was run during the pandemic period using remote assessment and intervention. Accordingly, a reduced number of physiological measurements were recorded during this time.

Results: