ESTRO 2024 - Abstract Book

S1633

Clinical - Lung

ESTRO 2024

Conclusion:

Data from RAPID-RT will be used to develop the optimal analysis strategy that allows rapid feedback of changes in patient outcomes from those treated with the previous standard-of-care. This study will also demonstrate how rapid-learning using RWD may provide prospective evidence in situations where RCTs are challenging. A programme of interviews are underway with patients who participated in the study to review the experience of the opt-out process, to ensure this method is accepted by patients, with simple study information minimising patient burden and ensuring inclusivity.

Keywords: opt-out, rapid-learning, real world data

References:

[1] A. McWilliam, J. Kennedy, C. Hodgson, E. Vasquez Osorio, C. Faivre- Finn, and M. van Herk, “Radiation dose to heart base linked with poorer survival in lung cancer patients,” Eur J Cancer, vol. 85, pp. 106– 113, Nov. 2017, doi: 10.1016/J.EJCA.2017.07.053. [2] A. McWilliam, A. Abravan, K. Banfill, C. Faivre- Finn, and M. van Herk, “Demystifying the Results of RTOG 0617: Identification of Dose Sensitive Cardiac Subregions Associated With Overall Survival,” Journal of Thoracic Oncology, vol. 18, no. 5, pp. 599 – 607, May 2023, doi: 10.1016/j.jtho.2023.01.085.