ESTRO 2024 - Abstract Book

S1667

Clinical - Lung

ESTRO 2024

Keywords: RTTT, ultracentral tumors, robotic SBRT

1473

Digital Poster

Cardioimaging in Stage III Lung Cancer Patients Undergoing ChemoRT: Preliminary CARE-RT Results

Valerio Nardone 1 , Roberta Grassi 1 , Maria Paola Belfiore 1 , Giuseppina De Marco 1 , Marco De Chiara 1 , Pietro Roccatagliata 1 , Mauro Buono 1 , Giovanni Cimmino 2 , Carminia Maria Della Corte 1 , Floriana Morgillo 1 , Fortunato Ciardiello 1 , Alfonso Reginelli 1 , Salvatore Cappabianca 1 1 University of Campania "L. Vanvitelli", Department of Precision Medicine, Naples, Italy. 2 University of Campania "L. Vanvitelli", Department of Translational Medical Science, Naples, Italy

Purpose/Objective:

In our prospective, single-center trial, we aim to assess both acute and delayed cardiac complications using advanced cardiac imaging techniques (CardiacCT and CardiacMRI) in patients diagnosed with locally advanced non small cell lung cancer (NSCLC) who are undergoing radical radiation therapy (RT).

Material/Methods:

We prospectively enrolled consecutive patients with stage III NSCLC eligible for radical RT in this trial. Prior to the commencement of their treatment and during follow-up, they underwent a cardiology evaluation, cardiac-MRI, and cardiac-CT. We collected personal information, comorbidities, related treatments, disease characteristics, timing and types of oncological therapies, as well as cardiological parameters obtained from clinical assessments, CT, and MRI. This preliminary analysis aims to describe the baseline characteristics of the patients included in our study.

Results:

Between November 2022 and October 2023, we enrolled 18 patients, consisting of 14 males (77.8%) and four females (22.2%), all of whom received concurrent or sequential chemo-radiotherapy. Eight patients (44.4%) were former smokers, while ten (55.6%) were active smokers. Concerning comorbidities, four patients (22.2%) had previously undergone cardiac surgery, and fourteen (77.8%) were taking medication for hypertension, with six (33.3%) also receiving treatment for diabetes. Despite these conditions, all patients were in good clinical condition with a PS-ECOG score of 0-1. Cardiologically, ten patients (55.6%) showed no symptoms, yet when assessed with cardiac-CT imaging using the Coronary Artery Disease Reporting and Data System (CAD-RADS), none received a score of 0. Six patients (33.3%) were scored as 1, four (22.2%) were scored as 3, and six (33.3%) were scored as 4. Cardiac-MRI revealed severe cardiac function impairment in four patients. Notably, a discrepancy between clinical cardiac examination and cardiac imaging was observed in six out of 14 patients, with two patients (11.1%) undergoing percutaneous transluminal coronary angioplasty (PTCA) after completing their oncological treatment.